11. Skin changes

Any changes in the appearance of a mole or birthmark could be indicative of skin cancer and should be evaluated. To remember which changes could be cause for concern, try using this memory aid, ABCDE.

• Asymmetry. One half of the mole or mark doesn’t look like the other.
• Border. The edges are irregular or blurred.
• Color. It’s varied or inconsistent, and it’s both black and brown.
• Diameter. It’s larger than the size of a pencil eraser.
• Evolving. It grows, bleeds or otherwise changes over time.

12. Pain that lasts

Persistent pain anywhere in your body that has no clear cause and doesn’t respond to standard treatments should be evaluated.

13. Persistent fatigue

A sudden, lasting change in your energy level, no matter how much sleep you get, can be a sign of lymphoma or leukemia.

14. Postmenopausal bleeding

There are a number of reasons you may experience bleeding after menopause, but if it persists, your doctor may want to check for cervical cancer or endometrial cancer.