Acquired mutations:

Most mutations occur after birth and are not genetically inherited. These diseases can be caused by smoking, radiation, viruses, cancer-causing chemicals, obesity, hormones, chronic infections, and a sedentary lifestyle.
Errors in cell growth: Mutations often occur during normal cell growth, but cells usually have mechanisms to correct these errors. However, this mechanism sometimes fails, allowing cancerous mutations to persist.
How do genetic mutations interact?
Inherited or acquired mutations interact to increase the risk of cancer. For example, inheriting one mutation may not directly cause cancer, but it may make you more susceptible to another mutation that causes the disease.